{"created":"2023-05-15T11:56:26.804031+00:00","id":107,"links":{},"metadata":{"_buckets":{"deposit":"5fe7c6dc-e94c-4088-b84d-d3d81e6a8070"},"_deposit":{"created_by":2,"id":"107","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"107"},"status":"published"},"_oai":{"id":"oai:kinwu.repo.nii.ac.jp:00000107","sets":["12:3:21:38"]},"author_link":["464","459","461","457","458","460","463","462","456"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"カルシウム キョウカジ ト セイゲンジ ニオケル ケッセイ オヨビ ニョウチュウ ノ カルシウム リン コツタイシャ マーカー ノ ヘンカ エイブン"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-12-15","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"62","bibliographicPageStart":"55","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"近畿福祉大学紀要"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田, 繁子"}],"nameIdentifiers":[{"nameIdentifier":"456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保田, 恵"}],"nameIdentifiers":[{"nameIdentifier":"457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金政, 泰弘"}],"nameIdentifiers":[{"nameIdentifier":"458","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヨシダ, シゲコ"}],"nameIdentifiers":[{"nameIdentifier":"459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"クボタ, メグミ"}],"nameIdentifiers":[{"nameIdentifier":"460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カネマサ, ヤスヒロ"}],"nameIdentifiers":[{"nameIdentifier":"461","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Shigeko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Megumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanemasa, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"カルシウム強化と制限時における血清中・尿中カルシウムとリン酸塩、骨型アルカリホスファターゼ、副甲状腺ホルモン(中間部)、1,25(OH)_2D_3、オステオカルシン、デオキシピリジノリンの変化を合わせて観察した。被験者は健康な男子で、4日間の調整期間中は日本人の栄養所要量を充たす食事を、7日間の実験期間中は3群とも同一の食事で、カルシウム以外の栄養素は栄養所要量を充たすように調整した。実験期間中はカルシウム300mg/日ベースとし、カルシウム350mg/日補充群をコントロール群(C群)、カルシウム1800mg/日補充群を強化群(S群)、カルシウム補充なしを制限群(R群)とした。血液試料は1,5,8日目の昼食前に採取し、尿試料は第2尿から翌日第1尿までの24時間尿を採取した。その結果、血清イオン化カルシウムと尿中カルシウム量は、3群間で有意な差はみられなかった。一方血清リンおよび尿中リンレベルはS群が最も低く、尿中リンは1日目、8日目はC群と、5日目はR群とに差がみられた。骨型アルカリホスファターゼ活性は1日目はR群がS群より低く、8日目はS群が低かった。5日目はS群が最も高くR群が最も低かった。R群8日目の骨型アルカリホスファターゼ活性は1日目より40%高く、S群では逆に8日目は1日目に対し50%低かった。デオキシピリジノリンには3群間に有意な差はみられなかったものの、C群が常に高かった。PTHレベルはC群が常に高かく8日目にはS群がR群より低かったが有意な差はみられなかった。また実験期間中のS群の1,25(OH)_2D_3レベルは常にR群より低かったが、オステオカルシンはS群が常に最も高かったが、群間の有意な差はみられなかった。これらの結果により、食事中への所要量を越えたカルシウム負荷は、血清および尿中カルシウム、リン酸、血清骨型アルカリホスファターゼ活性、オステオカルシン、PTH、1,25(OH)_2D_3レベルを骨吸収より骨形成優勢に整え、短期間での高カルシウム負荷は、骨粗鬆症予防に役立つことが示唆された。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The present study was designed to investigate changes in the levels of calcium and inorganic phosphorus (IP) in serum and urine when calcium was supplemented or restricted. And also serum bone specific alkaline phosphatase (b-ALP), mid-portion parathyroid hormone (PTH), 1,25 dihydroxyvitamin D (1,25(OH)_2D_3), osteocalsin (BGP) and urinary deoxypyridinoline (D-Pyr) were investigated. During the adjustment period (4d), healthy male subjects were given the same diet that satisfied recommended dietary allowance (RDA) for Japanese (650mg calcium). Then, during the 7-day experimental period, some groups received supplemental calcium to a 300mg base as follows : S group (n=4) 1800 mg/d; C group (n=3) 350 mg/d; R group (n=4) none. Blood samples were collected from each subject before lunch on days, 1, 5 and 8(see Fig.1). Also, samples from the second urination , day, 1, until the first urination, day 2 repeated for days 5 and 8, were collected for 24-h. The results showed that there was no significant difference in serum Ca^<2+> and urine calcium levels among the groups. There was no significant difference in serum IP levels too, but the S group's IP level was always the lowest of all groups. However, in the urination samples for days 1 and 8, the C group was higher than the S group, and on day 5, the R group was higher than the S group in IP levels. As for b-ALP activity, day 1 showed that the R group was lower than the S group (R<S), and on day 8 the S group was lower (R>S). In fact, on day 8 there was a 40% rise for the R group while the S group had a drop of 50%. Even so, on day 5 there was no statistical difference among the groups, though the S group was the highest and the R groups was the lowest. As for D-Pyr: there was no significant difference among the groups, but the C group was the highest. The PTH levels of R and S groups were lower than the C group, but not significant. On day 8, the S group's PTH level was lower than the R group's. Throughtout the experiment, the S group's 1,25 (OH)_2D_3 was always lower than the R group's, but the S group's, but the S group's BGP was always highest. These results suggest that the calcium overdose in their diets prearrange bone formation superior to bone resorption the level of serum or urine calcium, phosphate, and serum b-ALP, BGP, PTH and 1,25(OH)_2D_3, and high calcium supplementation in a short period is effective treatment for osteoporosis.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11887920","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Kinki Welfare University"},{"subitem_text_language":"en","subitem_text_value":"Okayama Prefectural University"},{"subitem_text_language":"en","subitem_text_value":"Tamano Institute of Health and Human Services"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"研究ノート"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Research Note"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"近畿福祉大学"},{"subitem_text_value":"岡山県立大学"},{"subitem_text_value":"玉野総合医療専門学校"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2001-12-15"}],"displaytype":"detail","filename":"KJ00004728807.pdf","filesize":[{"value":"6.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://kinwu.repo.nii.ac.jp/record/107/files/KJ00004728807.pdf"},"version_id":"41cf67dd-4f6f-432b-9f7c-4426b39fd32a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"カルシウム強化","subitem_subject_scheme":"Other"},{"subitem_subject":"カルシウム制限","subitem_subject_scheme":"Other"},{"subitem_subject":"骨代謝ホルモン","subitem_subject_scheme":"Other"},{"subitem_subject":"骨代謝マーカー","subitem_subject_scheme":"Other"},{"subitem_subject":"骨粗鬆症","subitem_subject_scheme":"Other"},{"subitem_subject":"calcium supplementation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"calcium restriction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"calcium metabolic hormone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biochemical markers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoporosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"カルシウム強化時と制限時における血清および尿中のカルシウム、リン、骨代謝マーカーの変化(英文)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カルシウム強化時と制限時における血清および尿中のカルシウム、リン、骨代謝マーカーの変化(英文)"},{"subitem_title":"The Change of Calcium, Phosphorus and Bone Metabolic Markers in Serum and Urine during the Calcium Supplementation and Restriction","subitem_title_language":"en"}]},"item_type_id":"1","owner":"2","path":["38"],"pubdate":{"attribute_name":"公開日","attribute_value":"2001-12-15"},"publish_date":"2001-12-15","publish_status":"0","recid":"107","relation_version_is_last":true,"title":["カルシウム強化時と制限時における血清および尿中のカルシウム、リン、骨代謝マーカーの変化(英文)"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-15T15:18:27.256885+00:00"}